abdominal pain

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Gut. 2009 Feb;58(2):196-201. Epub 2008 Sep 29

Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M.

INSERM U913, Nantes, France.

BACKGROUND: Growing evidence suggests that patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. We aimed to investigate (1) paracellular permeability in colonic biopsies of patients with IBS; and (2) the ability of soluble factors from colonic biopsies to reproduce these alterations in vitro.

“Your IBS Symptoms Are Experienced in Many Different Body Systems.“

Am J Gastroenterol. 2004 Sep;99(9):1774-8.

Okhuysen PC, Jiang ZD, Carlin L, Forbes C, DuPont HL.

Division of Infectious Diseases, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, JFB 1.728, Houston, TX 77096, USA.

OBJECTIVES: Irritable bowel syndrome (IBS) has been reported to complicate bacterial diarrhea. Because of the frequency of international travel and the common occurrence of bacterial diarrhea, we studied the occurrence of chronic gastrointestinal complaints and post-diarrhea IBS in North U.S. travelers to Mexico.

J Clin Gastroenterol. 2007 Apr;41(4):380-3.

Uz E, Türkay C, Aytac S, Bavbek N.

Department of Internal Medicine, Fatih University Medical School Ankara, Turkey.

GOALS: The aim of this study was to determine the prevalence of food hypersensitivity in Turkish patients with irritable bowel syndrome (IBS).

BACKGROUND: The IBS is a chronic disease of the gastrointestinal tract characterized by abdominal pain, distension, meteorism and either diarrhea or constipation. The role of diet in the pathogenesis of IBS remains controversial.

Med Klin (Munich). 2008 Jun 15;103(6):413-22; quiz 423-4.

Jankowiak C, Ludwig D.

Medizinische Klinik I, Bereich Gastroenterologie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Ratzeburger Allee 160, Lübeck. c.jankowiak@gmx.net

Celiac disease and lactose intolerance are both relatively frequent diseases with symptoms occurring after ingestion of certain food components.In celiac disease wheat gluten and related proteins of other cereals induce an inflammatory disease of the small intestine in predisposed individuals, leading to gastrointestinal and extraintestinal symptoms.

Aliment Pharmacol Ther. 2008 Jan 15;27(2):93-103. Epub 2007 Oct 23.

Lomer MC, Parkes GC, Sanderson JD.

Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK. miranda.lomer@kcl.ac.uk

BACKGROUND: Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance.

AIMS: To review current clinical practice and identify published literature on the management of lactose intolerance.

Praxis (Bern 1994). 2007 Feb 28;96(9):323-6.

Layer P, Keller J.

Israelitisches Krankenhaus in Hamburg, Akademisches Lehrkrankenhaus, Universität Hamburg. layer@ik-h.de

The irritable bowel syndrome is the most frequent and most important functional bowel disease. It is characterized by a combination of abdominal pain, alterations of bowel habits (diarrhea, constipation) and meteorism. Probably, visceral hypersensitivity, motility disturbances, food intolerance, immunologic and microbiologic alterations and psychosomatic influences contribute to symptoms. In a relevant subgroup of patients the disease is triggered by bacterial infection.

Am Fam Physician. 2003 May 15;67(10):2157-62.

Holten KB, Wetherington A, Bankston L.

Department of Family Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. keholtenmd@cmhregional.com

Diagnosing a patient who presents with abdominal pain and altered bowel habits can be challenging. Although serious organic illnesses can cause these symptoms, irritable bowel syndrome is commonly responsible. It can be difficult to properly evaluate these patients without overusing diagnostic tests and consultation.

Med Princ Pract. 2002 Jan-Mar;11(1):2-17.

Alaradi O, Barkin JS.

Division of Gastroenterology, School of Medicine/Mount Sinai Medical Center, University of Miami, Miami, Fla., USA.

Irritable bowel syndrome (IBS) comprises a major proportion of gastrointestinal and primary care practice worldwide. The past several years have seen the rapid evolution of a new and comprehensive model of IBS based on alterations in brain-gut interactions. Alterations in the bidirectional communication between the enteric nervous system and the central nervous system are implicated in the pathogenesis of IBS. 5-Hydroxytryptamine (5-HT; serotonin), a major neurotransmitter in the gastrointestinal tract, and its receptors 5-HT3 and 5-HT4 are involved in the control of gastrointestinal function.