Oxford Nutritional Services
Division of Signet Diagnostic Corporation
Many researchers have shown and reported that even the different “types” of Irritable Bowel Syndrome patients have a little bit different type of abnormal inflammation. Since this is the case, and if you could find what provokes the inflammation and avoid it, this would be much better than trying to block the results of inflammation or suppress inflammation with drugs. In 2002, this approach was suggested by one of the leaders in the Gastroenterology field to his fellow gastroenterologists. At that time, our affiliated Physicians and Dietitians had already begun using the approach recommended, because we had invented, developed, and patented the MRT (Mediator Release Test). MRT is a blood test that can identify what foods, flavorings, or chemicals in food your immune system is over reacting to. Once you know this, a doctor or dietitian can provide a plan specifically designed for YOU. This plan will show you how to change your eating habits to avoid those things that are making YOU sick. That’s much better than a diet based on what seems to make a lot of IBS patient sick so just avoid all that stuff.
The sad part is, people do not realize that if the inflammatory reactions are stopped, the “fatty foods” or “spicy foods” or “dairy foods” or “irritant chemicals” which make an IBS patient seem to get sick from a food “trigger” will not trigger anything much at all. Just like they don’t in a normal, NON-IBS gut. Indeed you can follow any of a number of popular and reputable diet plans which can help your symptoms, but not because they have identified the underlying inflammatory response which is making the bowel’s nervous system irritable in the first place. All they are doing is removing types and classes of foods which irritate an irritable bowel further, or unwittingly, it may be a food is seen to cause hypersensitivity reaction in many IBS patients. So that’s a lucky guess. The MRT test based LEAP program is very specific for you. It is an anti-inflammatory diet specific to each person. Each of us tolerates or does not tolerate a different list of foods or additives which cause different types of inflammatory reactions. You cannot get that specific information out of a book, from a food avoidance list, nor from any standard allergy testing.
“These findings suggest that subgrouping of IBS by bowel symptoms may identify distinct histomorphic phenotypes within IBS, which in turn suggests that treatment may need to be tailored to symptom subgroups. In view of the increasing evidence of histologic abnormalities in IBS, and providing that this is indeed a true organic bowel disease, might intervention to reduce the inflammation have utility? If such intervention was able to prevent the development or progression of IBS, then this would be of major clinical importance.”
If that is the case then the information we are sharing is of major clinical importance! Even more recently, articles have been published which describe in great detail the specific types of immune cells involved in the inflammation of IBS, and some of the things which could be causing this. All we have to do is connect-the-dots to our own research an publications that we made public several years ago at medical conferences and the picture of your abnormal immune responses, and what causes them, becomes very clear. People who talk about how this diet or that diet will avoid irritating the nerves of the IBS patients gut, which are somehow irritable, simply have missed the point that we know how they get irritable. The cause is clear and the solution then is even more obvious. Immune cells releasing irritating chemicals at the wrong time and in the wrong place, sort of like the juice of an orange sprayed in your eye sure irritates the nerves but in the mouth its nothing. So it is with your so called irritable bowel.
Histopathologic data demonstrate low-grade mucosal inflammation in a subset of patients with irritable bowel syndrome (IBS). This inflammatory infiltrate is mainly represented by increased numbers of T lymphocytes and mast cells lying in the lamina propria. The close apposition of immunocytes to gut nerves supplying the mucosa provides a basis for neuroimmune cross-talk, which may explain gut sensorimotor dysfunction and related symptoms in patients with IBS. A previous gastroenteritis (due to Campylobacter jejuni, Salmonella, Shigella, Escherichia coli, and, likely, viruses) is now an established etiologic factor for IBS (hence, postinfectious IBS). Other putative causes, such as undiagnosed food allergies, genetic abnormalities, stress, or bile acid malabsorption, may also promote and maintain a low-grade mucosal inflammation in IBS. The identification of mucosal inflammation in IBS has pathophysiologic implications and paves the way for novel therapeutic options.
The many science references you can find on this website provide a vast array of published medical information about the inflammatory response, and how it links to the symptoms of IBS. The references reflect what is now known about all facets of Irritable Bowel Syndrome as an actual disease. From all this information our testing and treatment solution, LEAP™ (Lifestyle, Eating, and Performance) was developed. We use a patented blood test to identify what is causing your excess inflammatory reactions then we teach you how to eliminate them. This can all be done without leaving your home or office.